HCID 12541574, compound → HCID 86651996, compound

HRID 1615370Notes

Reaction equation

HRID 1615370 reaction equation
I[C:2]1[C:10]2[C:5](=[CH:6][C:7]([CH:11]=[O:12])=[CH:8][CH:9]=2)[N:4]([CH2:13][O:14][CH2:15][CH2:16][Si:17]([CH3:20])([CH3:19])[CH3:18])[N:3]=1.[CH:21]([C:23]1[CH:35]=[CH:34][C:26]([CH2:27][N:28]2[CH2:33][CH2:32][O:31][CH2:30][CH2:29]2)=[CH:25][CH:24]=1)=[CH2:22]>>[O:31]1[CH2:32][CH2:33][N:28]([CH2:27][C:26]2[CH:34]=[CH:35][C:23](/[CH:21]=[CH:22]/[C:2]3[C:10]4[C:5](=[CH:6][C:7]([CH:11]=[O:12])=[CH:8][CH:9]=4)[N:4]([CH2:13][O:14][CH2:15][CH2:16][Si:17]([CH3:20])([CH3:19])[CH3:18])[N:3]=3)=[CH:24][CH:25]=2)[CH2:29][CH2:30]1

Participants

3

Reactant 2

HCID 12541574HCID 12541574, compoundHCID 581896963-iodo-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-indazole-6-carbaldehyde

Product 1

HCID 86651996HCID 86651996, compound

Procedure

According to the method of example A57A, 3-iodo-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-indazole-6-carbaldehyde (402 mg, 1 mmol) was reacted with 4-(4-vinylbenzyl)morpholine (304 mg, 1.5 mmol) to give the title compound upon silica gel purification (1:1 hexane/ethyl acetate) as a yellow solid (120 mg, 25%). MS ESI 478.3 [M+H]+, calcd for [C27H35N3O3Si+H]+ 478.2.

Sources & evidence

ORD record
ord-1117fb65b8ff4bef9727092ee0561889
Source dataset
uspto-grants-2014_07
Patent number
US08765748B2

Reaction notes

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