Ammonia → HCID 67204634, compound

Participants

Reaction Conditions

Reaction Steps

1-(6-Chloropyrimidin-4-yl)-6-(3-nitrophenyl)-1H-indole (1 g, 2.86 mmol) was dissolved in DMSO (15 mL) in a sealed reactor. After adding 2.0 M ammonia solution in isopropanol (15 mL, 30 mmol), the reaction mixture was stirred at 100° C. for 15 hours. After cooling to room temperature and adding water (70 mL), the reaction mixture was stirred at room temperature for 1 hour. Thus prepared solid was filtered, washed with water, and dried in the air. 6-(6-(3-Nitrophenyl)-1H-indol-1-yl)pyrimidin-4-amine (850 mg) was yielded as white solid.

Provenance & Evidence