HCID 67204634, compound → HCID 67203782, compound

Participants

Reaction Steps

6-(6-(3-Nitrophenyl)-1H-indol-1-yl)pyrimidin-4-amine (400 mg, 1.21 mmol) was dissolved in methanol/dioxane (1:1, 6 mL) and Raney nickel was added. The mixture solution was stirred under hydrogen gas (1 atm) for 1.5 hours. The mixture solution was filtered through a diatomite pad, and the filtrate was concentrated under reduced pressure. After adding methylene chloride to the residue, thus prepared solid was filtered. 6-(6-(3-Aminophenyl)-1H-indol-1-yl)pyrimidin-4-amine (158 mg) was yielded as white solid. Concentration of the filtrate followed by column chromatography (silica gel, EA:Hx=1:1→MC:MeOH=20:1) further gave the target compound.

Provenance & Evidence