Stannous chloride dihydrate → HCID 67203963, compound

Participants

Reaction Conditions

Reaction Steps

6-(6-(2-Methyl-5-nitrophenyl)-1H-indol-1-yl)pyrimidin-4-amine (130 mg, 0.38 mmol) was dissolved in ethanol and, after adding SnCl2.2H2O (425 mg, 1.88 mmol), the mixture was stirred at 100° C. for 3 hours. The reaction mixture was added to sodium bicarbonate aqueous solution and extracted with ethyl acetate. The combined organic layer was washed with brine, dried with magnesium sulfate, and concentrated under reduced pressure. Purification of the residue by column chromatography (silica gel, MC:MeOH=20:1) yielded 6-(6-(5-amino-2-methylphenyl)-1H-indol-1-yl)pyrimidin-4-amine (83 mg).

Provenance & Evidence