Ammonia → HCID 67204099, compound

Participants

Reaction Conditions

Reaction Steps

Ammonia solution (2.0 M in isopropanol) was added to 1-(2-(methylsulfinyl)pyrimidin-4-yl)-6-(3-nitrophenyl)-1H-indole (102 mg) dissolved in isopropanol. After stirring at 100° C. for 3 hours and cooling to room temperature, the reaction mixture was added to water. The aqueous layer was extracted with ethyl acetate. The combined organic layer was washed with brine, dried with magnesium sulfate, and concentrated under reduced pressure. 4-(6-(3-Nitrophenyl)-1H-indol-1-yl)pyrimidin-2-amine (76.8 mg) was yielded.

Provenance & Evidence