Water → HCID 22557720, compound

Participants

Reaction Conditions

Reaction Steps

4-fluorobenzoic acid tert-butyl ester (19.6 g, 100 mmol) was dissolved in dimethyl sulfoxide (hereinafter referred to as DMSO) (50 ml), and potassium carbonate (20.7 g, 150 mmol) and 4-aminopiperidine (11.0 g, 110 mmol) were added thereto, followed by stirring at 120° C. for 17 hours. After the reaction mixture was cooled to room temperature, water was added to the mixture, and the precipitate was collected by filtration, thereby obtaining 4-(4-aminopiperidin-1-yl)-benzoic acid tert-butyl ester (23.3 g, 84%) as a milky-white solid.

Provenance & Evidence