Water → HCID 71073900, compound

Participants

Reaction Conditions

Reaction Steps

The N-(4-(3-tosyloxypropyl)phenyl)-4-tert-butoxycarbonylaminopiperidine (330 mg, 0.68 mmol) obtained in Example 8(4) was dissolved in a mixed solvent of acetonitrile (5 ml) and DMF (5 ml), and 1,2,4-triazole (54 mg, 0.81 mmol) and potassium carbonate (187 mg, 1.35 mmol) were added thereto, followed by stirring at 60° C. for 1 hour. After the reaction mixture was cooled to room temperature, water was added thereto, and the precipitate was collected by filtration, thereby obtaining N-(4-(3-(1,2,4-triazol-1-yl)-propyl)-phenyl)-4-tert-butoxycarbonylaminopiperidine (192 mg, 74%).

Provenance & Evidence