4-Methoxycarbonylphenylboronic acid → HCID 86680686, compound

HRID 1615449Notes

Reaction equation

HRID 1615449 reaction equation
O(P(O[C:18]1[N:24]([C:25]([O:27][C:28]([CH3:31])([CH3:30])[CH3:29])=[O:26])[CH2:23][CH2:22][CH2:21][O:20][CH:19]=1)(OC1C=CC=CC=1)=O)C1C=CC=CC=1.[CH3:32][O:33][C:34]([C:36]1[CH:41]=[CH:40][C:39](B(O)O)=[CH:38][CH:37]=1)=[O:35]>>[CH3:32][O:33][C:34]([C:36]1[CH:41]=[CH:40][C:39]([C:18]2[N:24]([C:25]([O:27][C:28]([CH3:29])([CH3:30])[CH3:31])=[O:26])[CH2:23][CH2:22][CH2:21][O:20][CH:19]=2)=[CH:38][CH:37]=1)=[O:35]

Participants

3

Reactant 2

HCID 27343694-Methoxycarbonylphenylboronic acidHCID 86680687HCID 86680687, compound

Product 1

HCID 86680686HCID 86680686, compoundYield 41%

Procedure

This compound was prepared from tert-butyl 3-((diphenoxyphosphoryl)oxy)-6,7-dihydro-1,4-oxazepine-4(5H)-carboxylate and (4-methoxycarbonylphenyl)boronic acid according to the procedure described above in Example 2 (Step 3). The product was isolated as a white solid (41% yield); 1H-NMR (CDCl3) 1.11 (7H, s), 1.61 (2H, s), 2.16-2.18 (2H, m), 3.93-4.22 (7H, m), 6.32 (1H, s), 7.29-7.32 (2H, m), 7.97 (2H, d); MS ES(+) 278.1 (M+-tBu).

Sources & evidence

ORD record
ord-404eb2f502bd4955bd7a23907bfd6080
Source dataset
uspto-grants-2014_07
Patent number
US08765751B2

Reaction notes

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