6-(3-(Pyrrolidin-1-yl)prop-1-ynyl)pyrrolo[2,1-f][1,2,4]triazin-4-amine → 6-(3-(Pyrrolidin-1-yl)propyl)pyrrolo[2,1-f][1,2,4]triazin-4-amine

Participants

Reaction Steps

In a round-bottom flask, the compound (269 mg, 1.14 mmol) prepared in Example 11, palladium/carbon (10%, 20 mg) and methanol (10 mL) was added and the atmosphere was replaced with hydrogen gas at 1 atm. After 18 hours, the mixture was filtered through celite and the celite pad was washed with methanol. The methanol was removed in vacuo to obtain the title compound (257 mg) having the following physical data.

Provenance & Evidence