Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Acryloyl chloride | HCID 13140 | — |
| Reactant | HCID 66614357 | HCID 66614357 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 66601644 | HCID 66601644 | — |
Reaction Steps
The compound (27.6 mg, 0.057 mmol) prepared in Example 31 was taken up in 1 mL DCM (dry) under argon and triethylamine (23.8 μl, 0.171 mmole) was added. The reaction was cooled to −10° C. and the acryloyl chloride (4.17 μl, 0.051 mmole) was added via syringe slowly. The reaction quenched with methanol and solvent removed under vacuum. The title compound (10.5 mg) having the following data was isolated by prep-HPLC.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08765754B2 |
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| Source dataset | uspto-grants-2014_07 |
|---|
| ORD ID | ord-e9d3f25c20de45c7b146303e05d677fb |
|---|
| Source note | uspto-grants-2014_07 |
|---|
