Water → 4-(4-chlorophenyl)-4-hydroxy-2-pyridin-4-yl-4,5,6,7-tetrahydro-8H-cyclohepta[b]thiophen-8-one

Participants

Reaction Conditions

Reaction Steps

To a solution of 4-(4-chlorophenyl)-2-pyridin-4-yl-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-4-ol (46.3 mg, 0.130 mmol) in 1,4-dioxane (3.0 mL, 38.0 mmol), acetonitrile (3.0 mL, 57 mmol) and water (2 mL, 100 mmol) were added copper(II) sulfate pentahydrate (145.0 mg, 0.580 mmol) and potassium persulfate (180.0 mg, 0.666 mmol). The reaction mixture was stirred for 16 hr at 90° C. during which time a yellow-greenish suspension was obtained and the blue color of the reaction disappeared.

Provenance & Evidence