Hydrochloric Acid → HCID 68183124, compound

Participants

Reaction Steps

To a solution of 4-{3-[(tert-butoxycarbonyl)amino]-1-(4-chlorophenyl)propyl}-2-(morpholin-4-yl)-1,3-thiazole-5-carboxylic acid (0.304 g, 0.631 mmol) in DCM (5.9 mL) was added a solution of hydrogen chloride in dioxane (4 M, 3.1 mL, 12 mmol) and the mixture was stirred at room temperature for 1 hour. The solvent was evaporated and the residue was then azeotroped with toluene and dried under vacuum to give the product (0.284 g, 108%) which was used directly in the next step. LCMS: (AA) ES+ 382, 384.

Provenance & Evidence