HCID 68182884, compound → HCID 68183401, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of methyl rel-(4R,5R)-6-allyl-4-(3,4-dichlorophenyl)-2-(morpholin-4-yl)-7-oxo-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-5-carboxylate (0.344 g, 0.714 mmol) and rhodium(III)chloride, (22.2 mg, 0.106 mmol) in 1-propanol (9.0 mL) was heated in a sealed tube under argon at 120° C. for 50 h. The reaction mixture was evaporated and purified by silica gel chromatography to afford the product as a white solid (0.278 g, 88%). LCMS: (AA), ES+: 441, 443, 1H NMR (400 MHz, CDCl3) δ 7.38 (d, J=8.3 Hz, 1H), 7.34-7.25 (m, 1H), 7.04 (dd, J=8.3, 2.0 Hz, 1H), 5.68 (s, 1H), 5.57 (s, 1H), 4.59 (d, J=2.9 Hz, 1H), 4.20-4.19 (m, 1H), 3.81-3.79 (m, 4H), 3.74 (s, 3H), 3.20-3.18 (m, 4H).

Provenance & Evidence