2-Aminopyridine → HCID 178425983, compound

HRID 1615622Notes

Reaction equation

HRID 1615622 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[NH2:7].[C:8]1([CH3:21])[CH:13]=[C:12]([CH3:14])[CH:11]=[C:10]([CH3:15])[C:9]=1[S:16]([O:19][NH2:20])(=[O:18])=[O:17]>C(Cl)Cl>[NH2:20][N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]1=[NH2+:7].[CH3:15][C:10]1[CH:11]=[C:12]([CH3:14])[CH:13]=[C:8]([CH3:21])[C:9]=1[S:16]([O-:19])(=[O:18])=[O:17]

Participants

4

Reactant 2

HCID 104392-AminopyridineHCID 11830845O-(2,4,6-Trimethylbenzenesulfonyl)hydroxylamine

Product 1

HCID 178425983HCID 178425983, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A mixture of pyridin-2-amine (6.6 g, 20.0 mmol) in DCM (15 mL) was stirred at room temperature, and O-(mesitylsulfonyl)hydroxylamine (1.0 g, 10.0 mmol) was added slowly. The reaction mixture was stirred at room temperature for 12 h, and the solvent was removed under vacuum. The crude product was used for next step without further purification. ESI MS: m/z 110 [M+H]+.

Workup

  1. stirringThe reaction mixture was stirred at room temperature for 12 h
  2. customthe solvent was removed under vacuum
  3. customThe crude product was used for next step without further purification

Sources & evidence

ORD record
ord-c3578307034440bdb755f0d3ffe6b1ab
Source dataset
uspto-grants-2014_07
Patent number
US08765760B2

Reaction notes

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