2-Oxobutanoic Acid → ethyl acetoacetate, sodium salt

To a solution of 2-oxobutanoic acid (6.0 g, 58.8 mmol) in EtOH (100 mL) was added sulfuric acid (1 mL) at room temperature. The resulting mixture was stirred for 4 h under reflux. The solvent was removed, and the residue was diluted with water (50 mL) and the pH was adjusted to ˜7 with a solution of NaOH (1 N). The mixture was extracted with EtOAc (100 mL×3). The combined organic layer was dried over sodium sulfate and concentrated to give ethyl 2-oxobutanoate (7.5 g, 98% yield). ESI MS: m/z 131 [M+H]+.

1. temperatureunder reflux
2. customThe solvent was removed
3. additionthe residue was diluted with water (50 mL)
4. extractionThe mixture was extracted with EtOAc (100 mL×3)
5. dry with materialThe combined organic layer was dried over sodium sulfate
6. concentrationconcentrated

ORD record

ord-4fc4ec07009b45feaad03a2526c8091d

Source dataset

uspto-grants-2014_07

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08765760B2