HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → methyl (S)-2-benzylamino-3-cycloheptyl-propionate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Benzyl Bromide | HCID 7498 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Methyl (S)-2-amino-3-cycloheptylpropanoate | HCID 68795663 | — |
| Solvent | Water | HCID 962 | — |
| Product | methyl (S)-2-benzylamino-3-cycloheptyl-propionate | HCID 68790091 | — |
Reaction Steps
1.04 g (5.22 mmol) methyl (S)-2-amino-3-cycloheptyl-propionate were stirred with 0.62 ml (5.22 mmol) benzylbromide, 1.44 g (10.4 mmol) potassium carbonate and 20 ml DMF at 100° C. for 3.5 h. Then water was added and the mixture was extracted with ethyl acetate. The organic phase was evaporated down and the residue was purified by flash chromatography.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08765763B2 |
| Source dataset | uspto-grants-2014_07 |
| ORD ID | ord-a9a63f0c461241f7a8b0287ae3d987f5 |
| Source note | uspto-grants-2014_07 |