methyl (S)-2-(benzyl-{2-(3,5-difluoro-phenyl)-2-[hydroxyimino]-ethyl}-amino)-3-cycloheptyl-propionate → (3S)-3-(cycloheptylmethyl)-6-(3,5-difluorophenyl)piperazin-2-one

Participants

Reaction Steps

Under a hydrogen atmosphere 0.590 g (1.29 mmol) methyl (S)-2-(benzyl-{2-(3,5-difluoro-phenyl)-2-[hydroxyimino]-ethyl}-amino)-3-cycloheptyl-propionate and 0.10 g palladium on charcoal (10%) in 10 ml of methanol were hydrogenated for 3 days at 50° C. and 3.45 bar hydrogen pressure. After elimination of the catalyst the filtrate was concentrated by rotary evaporation. The residue was stirred with petroleum ether and diisopropylether and filtered off.

Provenance & Evidence