Sodium hydride → HCID 68154739, compound

Participants

Reaction Steps

Under a nitrogen atmosphere 10 mg (0.23 mmol) sodium hydride were added at 0° C. to 90 mg (0.21 mmol) (2S)-tert-butyl-2-(cycloheptylmethyl)-5-(3,5-difluorophenyl)-3-oxopiperazine-1-carboxylate in 3 ml DMF. After 30 min at 0° C. 0.02 ml (0.26 mmol) methyl bromoacetate were added and then the reaction mixture was heated to RT overnight.

Provenance & Evidence