Sodium hydride → HCID 68154152, compound

Participants

Reaction Steps

28 mg (0.66 mmol) sodium hydride were added to 0.21 g (0.55 mmol) tert-butyl 3-(3-fluorophenyl)-5-oxo-8,11-dioxa-1,4-diazaspiro[5.6]dodecane-1-carboxylate in 20 ml DMF. After 20 min at RT 63 μl (0.65 mmol) methyl bromoacetate were added dropwise at 0° C. Then the mixture was stirred for 30 min in the ice bath and then for 5 h at RT. The reaction mixture was poured onto water poured and extracted with ethyl acetate. The organic phase was washed with water, dried and evaporated down.

Provenance & Evidence