Lithium Hydroxide → HCID 68154501, compound

Participants

Reaction Steps

15 mg (0.62 mmol) lithium hydroxide were added to 0.25 g (0.55 mmol) tert-butyl 3-(3-fluorophenyl)-4-(2-methoxy-2-oxoethyl)-5-oxo-8,11-dioxa-1,4-diazaspiro[5.6]dodecane-1-carboxylate in 5 ml THF and 1 ml of water. The mixture was stirred for 2 h at RT and then the MeOH was distilled off. The residue was mixed with water and acidified with formic acid. The aqueous phase was extracted with ethyl acetate. The ethyl acetate phase was dried and evaporated down.

Provenance & Evidence