HCID 178525214, compound → HCID 68764704, compound

Participants

Reaction Steps

4.2 g (9.4 mmol) ethyl (rac)-E/Z-{benzyl-[2-(3,5-difluoro-phenyl)-2-hydroxyimino-ethyl]-amino}-(tetrahydro-pyran-4-yl)-acetate in 100 ml of ethanol were hydrogenated under a hydrogen atmosphere together with 0.80 g of 10% palladium charcoal for 20 h at 50° C. More catalyst was added and the mixture was hydrogenated at 70° C. The catalyst was removed by suction filtering and the solvent was evaporated down. The residue was dissolved in ethanol, combined with 2 g sodium hydrogen carbonate and refluxed overnight. After cooling the insoluble constituents of the reaction mixture were suction filtered. The filtrate was evaporated down. The residue was purified by flash chromatography. The fractions were evaporated down and the residue was triturated with diisopropylether. The precipitate was suction filtered and dried.

Provenance & Evidence