Sodium hydride → HCID 68154662, compound

Participants

Reaction Steps

At 0° C. 0.16 g (3.7 mmol) sodium hydride was added to 1.30 g (3.3 mmol) tert-butyl 5-(3,5-difluorophenyl)-3-oxo-2-(tetrahydro-2H-pyran-4-yl)piperazine-1-carboxylate (isomer mixture 2) in 20 ml DMF. After 20 min 0.36 ml (3.7 mmol) methyl bromoacetate were added dropwise while cooling with an ice bath. Then the mixture was stirred for 30 min in the ice bath and for 5 h at RT. The reaction mixture was poured onto water and extracted with ethyl acetate. The organic phase was washed with water, dried and evaporated down.

Provenance & Evidence