Hydrochloric Acid → N-(5-chloro-2'-oxo-1,1',2',3-tetrahydrospiro[inden-2,3'-pyrrolo[2,3-b]pyridin]-6-yl)-2-((R)-3-(3,5-difluorophenyl)-5-oxo-8,11-dioxa-1,4-diazaspiro[5.6]dodecan-4-yl)acetamide

Participants

Reaction Conditions

Reaction Steps

40 mg (0.06 mmol) (3R)-tert-butyl 4-(2-(5-chloro-2′-oxo-1,1′,2′,3-tetrahydrospiro[inden-2,3′-pyrrolo[2,3-b]pyridin]-6-ylamino)-2-oxoethyl)-3-(3,5-difluorophenyl)-5-oxo-8,11-dioxa-1,4-diazaspiro[5.6]dodecane-1-carboxylate were combined with 30 ml of a 1N methanolic hydrochloric acid solution and stirred for 1 h at 50° C. The reaction mixture was concentrated by rotary evaporation. The residue was taken up in water and adjusted to pH=8 with saturated NaHCO3 solution. The precipitate formed was suction filtered, washed with water and dried.

Provenance & Evidence