Hydrochloric Acid → N-((R)-2'-oxo-1,1',2',3-tetrahydrospiro[inden-2,3'-pyrrolo[2,3-b]pyridin]-5-yl)-2-((R)-5-oxo-3-phenyl-8,11-dioxa-1,4-diazaspiro[5.6]dodecan-4-yl)acetamide

Participants

Reaction Conditions

Reaction Steps

0.27 g (0.41 mmol) (R)-tert-butyl 5-oxo-4-(2-oxo-2-((R)-2′-oxo-1,1′,2′,3-tetrahydrospiro[inden-2,3′-pyrrolo-[2,3-b]pyridin]-5-ylamino)ethyl)-3-phenyl-8,11-dioxa-1,4-diazaspiro[5.6]-dodecane-1-carboxylate in 5 ml of methanol were combined with 10 ml of a 1.25 M methanolic hydrochloric acid and stirred for 3 h at 50° C. The reaction mixture was concentrated by rotary evaporation and neutralised with saturated NaHCO3 solution. The precipitate formed was suction filtered, washed with water and dried.

Provenance & Evidence