1-Hydroxybenzotriazole → HCID 49842720, compound

Participants

Reaction Conditions

Reaction Steps

0.23 g (0.52 mmol) 2-(1-(tert-butoxycarbonyl)-3-(3-fluorophenyl)-5-oxo-8,11-dioxa-1,4-diazaspiro[5.6]dodecan-4-yl)ethanoic acid, 0.15 mg (0.58 mmol) (R)-5-amino-1,3-dihydrospiro[inden-2,3′-pyrrolo[2,3-b]pyridin]-2′(1′H)-one, 0.13 g (0.70 mmol) 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride, 95 mg (0.7 mmol) HOBT, 0.08 ml (0.58 mmol) TEA and 2 ml DMF were stirred overnight at RT. The mixture was concentrated by rotary evaporation. The residue was combined with 15 ml of a 1.25M methanolic hydrochloric acid and stirred for 2 h at 50° C. The reaction mixture was evaporated down and purified by HPLC.

Provenance & Evidence