Hydrochloric Acid → Methyl 1-amino-1-cyclopentanecarboxylate, HCl

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Reaction Steps

A solution of 1-aminocyclopentanecarboxylic acid (20.0 g, 155 mmol) in MeOH (300 mL) was saturated with HCl (g), aged for 30 min, and saturated again with HCl (g). The mixture was aged at ambient temperature for 2 h and concentrated to dryness in vacuo. To the white solid was added saturated aqueous NaHCO3 (350 mL), carefully, with ice cooling, and the resulting mixture was extracted with EtOAc (4×250 mL). The combined organic extracts were dried over Na2SO4, filtered, and concentrated in vacuo to give the title compound. MS: m/z=144 (M+1).

Provenance & Evidence