(R)-5-Amino-1,3-dihydrospiro[indene-2,3'-pyrrolo[2,3-b]pyridin]-2'(1'H)-one → HCID 58118670, compound

HRID 1615824Notes

Reaction equation

HRID 1615824 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([C@@H:9]2[CH2:18][CH2:17][C:12]3([CH2:16][CH2:15][CH2:14][CH2:13]3)[C:11](=[O:19])[NH:10]2)[CH:5]=[C:6]([F:8])[CH:7]=1.N[C:21]1[CH:22]=C2C(=C[CH:38]=1)C[C@]1(C3C(=NC=CC=3)NC1=O)C2>>[CH2:22]([N:10]1[C@H:9]([C:4]2[CH:3]=[C:2]([F:1])[CH:7]=[C:6]([F:8])[CH:5]=2)[CH2:18][CH2:17][C:12]2([CH2:16][CH2:15][CH2:14][CH2:13]2)[C:11]1=[O:19])[CH:21]=[CH2:38]

Participants

3

Reactant 2

HCID 53260812(R)-5-Amino-1,3-dihydrospiro[indene-2,3'-pyrrolo[2,3-b]pyridin]-2'(1'H)-oneHCID 58118682HCID 58118682, compound2×

Product 1

HCID 58118670HCID 58118670, compound

Procedure

Prepared from (8S)-8-(3,5-difluorophenyl)-7-azaspiro[4.5]decan-6-one (Intermediate 16) by a procedure identical to that described in Intermediate 3 Step B. MS: m/z=306 (M+1).

Sources & evidence

ORD record
ord-4166bc0a63b6492993e08b6d9b638217
Source dataset
uspto-grants-2014_07
Patent number
US08765759B2

Reaction notes

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