1-Aminocyclohexanecarboxylic acid → Methyl 1-aminocyclohexane-1-carboxylate hydrochloride

HRID 1615830Notes

Reaction equation

HRID 1615830 reaction equation
[C:1](OC(=O)NC(C1C=C(F)C=C(F)C=1)(C)C=O)(C)(C)C.[ClH:21].[NH2:22][C:23]1([C:28]([O:30][CH3:31])=[O:29])[CH2:27][CH2:26][CH2:25][CH2:24]1.NC1(C(O)=O)CCCCC1>>[ClH:21].[NH2:22][C:23]1([C:28]([O:30][CH3:31])=[O:29])[CH2:27][CH2:26][CH2:25][CH2:24][CH2:1]1

Participants

4

Reactant 3

HCID 13661-Aminocyclohexanecarboxylic acidHCID 11513856Methyl 1-amino-1-cyclopentanecarboxylate, HClHCID 86616399tert-butyl N-[2-(3,5-difluorophenyl)-1-oxopropan-2-yl]carbamate

Product 1

HCID 22645079Methyl 1-aminocyclohexane-1-carboxylate hydrochloride

Procedure

Essentially following the procedures described in Intermediate 1 for methyl 1-aminocyclopentanecarboxylate hydrochloride, but using 1-aminocyclohexanecarboxylic acid in place of 1-aminocyclopentanecarboxylic acid, the title compound was obtained. MS: m/z=158 (M+1).

Sources & evidence

ORD record
ord-3167c0e51adc4469b19dc1f0536db585
Source dataset
uspto-grants-2014_07
Patent number
US08765759B2

Reaction notes

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