Water → HCID 58118671, compound

Participants

Reaction Conditions

Reaction Steps

To a stirred solution of O-ethyl S-[(2R)-2′-oxo-1′-{[2-(trimethylsilyl)ethoxy]methyl}-1,1′,2′,3-tetrahydrospiro[indene-2,3′-pyrrolo[2,3-b]pyridin]-5-yl]carbonodithioate from Step B (740 mg, 1.52 mmol) in EtOH (4 mL) was added 1 N NaOH (3.0 mL, 3.0 mmol). The resulting suspension was heated at 60° C. for 90 min, then cooled and poured into H2O (50 mL). The mixture was extracted with EtOAc (2×70 mL), and the combined organic layers were washed with brine (30 mL), dried over Na2SO4, filtered, and concentrated in vacuo to yield the title compound. MS: m/z=462 (M+Na+CH3CN).

Provenance & Evidence