Hydrogen Bromide → HCID 66864394, compound

Participants

Reaction Conditions

Reaction Steps

To a suspension of (2R)-6-amino-2′-oxo-1,1′,2′,3-tetrahydrospiro[indene-2,3′-pyrrolo[2,3-b]pyridine]-5-carbonitrile (200 mg, 0.72 mmol) in 25% HBr at 0° C. was added a solution of sodium nitrite (61.4 mg, 0.89 mmol) in H2O (0.3 mL) dropwise. The cooled mixture was then added to a cooled solution of copper(I)bromide (107 mg, 0.746 mmol) in 48% HBr (0.557 mL, 4.92 mmol). The reaction mixture was stirred at 0° C. for 1 h then warmed to ambient temperature. H2O (5 mL) was added and the mixture was made basic by addition of concentrated NH4OH. The resulting precipitate was collected by filtration and washed with H2O to provide the title compound in sufficient purity for the next step. MS: m/z=341 (M+1).

Provenance & Evidence