HCID 44224224, compound → HCID 44468572, compound

Participants

Reaction Steps

5-{(1E)-3-[(8R)-8-(3,5-difluorophenyl)-8-methyl-10-oxo-6,9-diazaspiro[4.5]dec-9-yl]prop-1-en-1-yl}-1,3-dihydrospiro[indene-2,3′-pyrrolo[2,3-b]pyridin]-2′(1′H)-one (the first eluting peak of Example 1) (32 mg, 0.058 mmol) was dissolved in 1 mL of methanol and hydrogenated using an H-Cube apparatus and 10% Palladium on carbon cartridge while eluting with 10% acetic acid in methanol. The reaction was concentrated in vacuo and partitioned between ethyl acetate and 10% sodium bicarbonate. The layers were separated. The organic layer was washed with brine, dried over sodium sulfate, filtered and conc in vacuo to yield the title compound MS: m/z=557 (M+1), HRMS: m/z=557.2713 (M+1); calculated m/z=557.2723 (M+1) for C33H35F2N4O2.

Provenance & Evidence