Pentafluorophenyl Trifluoroacetate → HCID 86650290, compound

Participants

Reaction Steps

To a stirred solution of [(8R)-6-(tert-butoxycarbonyl)-8-(3,5-difluorophenyl)-8-methyl-10-oxo-6,9-diazaspiro[4.5]dec-9-yl]acetic acid (254 mg, 0.579 mmol, described in Intermediate 21) in DMF (2 mL) was added pentafluorophenyl trifluoroacetate (0.7 mL, 4.07 mmol). The reaction mixture was stirred for 4 h at ambient temperature, then partitioned between saturated aqueous NaHCO3 (30 mL) and EtOAc (50 mL). The organic layer was dried over Na2SO4, filtered, and concentrated in vacuo. The crude product was purified on silica gel, eluting with a gradient of hexanes:EtOAc—100:0 to 0:100, to provide the title compound.

Provenance & Evidence