Water → 2-Amino-4-((3-phenylpropyl)amino)nicotinonitrile

Participants

Reaction Steps

Prepared according to the methods above using 2-azido-4-((3-phenylpropyl)amino)nicotinonitrile (35 mg, 0.126 mmol) in tetrahydrofuran (1.5 mL), trimethylphosphine 1.0 M in tetrahydrofuran (0.629 mL, 0.629 mmol) and water (0.011 mL, 0.629 mmol) at rt for 3.5 hours to give the desired product as an off-white solid (11 mg). LC/MS (253, [M+H]); 1H NMR (400 MHz, CHLOROFORM-d) δ 7.85-7.78 (m, 1H), 7.37-7.29 (m, 2H), 7.26-7.23 (m, 1H), 7.22-7.16 (m, 2H), 5.92 (d, J=6.0 Hz, 1H), 5.17 (br. s., 2H), 4.94 (br. s., 1H), 3.30-3.20 (m, 2H), 2.74 (t, J=7.5 Hz, 2H), 2.00 (quin, J=7.3 Hz, 2H).

Provenance & Evidence