HCID 86696512, compound → HCID 86696513, compound

Participants

Reaction Steps

A mixture of benzyl ((2-(5-fluoropyrimidin-2-yl)cyclopropyl)methyl)carbamate (180 mg, 0.597 mmol), 10% palladium on carbon (63 mg) in MeOH (10 mL) was shaken in a Parr shaker under hydrogen (10 psi) for 2 h. The reaction mixture was filtered and the filtrate was concentrated. The residue purified by silica gel chromatography using 0-20% 2.0 M ammonia in MeOH/EtOAc as the eluent to give (2-(5-fluoropyrimidin-2-yl)cyclopropyl)methanamine as a yellowish oil (48 mg, 48%). 1H NMR (400 MHz, CHLOROFORM-d) d 8.40 (s, 2H), 2.81-2.66 (m, 2H), 2.11 (dt, J=8.5, 4.4 Hz, 1H), 1.70-1.58 (m, 1H), 1.30 (bs, 2H, NH2), 1.28 (m, 1H), 0.97 (ddd, J=8.5, 6.0, 4.3 Hz, 1H). LCMS: M+1=168.

Provenance & Evidence