HCID 12088083, compound → HCID 71735755, compound

Participants

Reaction Steps

A mixture of 8-chloro-3-(cyclopropylmethyl)-7-iodo-[1,2,4]triazolo[4,3-a]pyridine (50 mg, 0.150 mmol) and (2-(pyridin-4-yl)cyclopropyl)methanamine (26.7 mg, 0.180 mmol) was reacted in a manner similar to Example 1 to give 8-chloro-3-(cyclopropylmethyl)-N-((2-(pyridin-4-yl)cyclopropyl)methyl)-[1,2,4]triazolo[4,3-a]pyridin-7-amine (25.7 mg, 47.5%). 1H NMR (500 MHz, DMSO-d6) δ 8.35 (d, J=6.1 Hz, 2H), 8.23 (d, J=7.6 Hz, 1H), 7.06 (d, J=6.1 Hz, 2H), 6.90 (d, J=7.6 Hz, 1H), 6.42 (t, J=6.1 Hz, 1H), 2.95 (d, J=6.7 Hz, 2H), 1.95 (dd, J=8.7, 4.4 Hz, 1H), 1.48 (br. s., 1H), 1.19-1.09 (m, 2H), 1.09-1.00 (m, 1H), 0.50 (d, J=6.4 Hz, 2H), 0.25 (d, J=4.6 Hz, 2H). LCMS: M+1=354.2.

Provenance & Evidence