HCID 71735429, compound → HCID 71736408, compound

Participants

Reaction Steps

Racemic trans 8-chloro-3-(cyclopropylmethyl)-N-((2-phenylcyclopentyl)methyl)-[1,2,4]triazolo[4,3-a]pyridin-7-amine was resolved by chiral preparative HPLC using a Chiralcel OJ 21×250 mm, 10 micron column with a 30% ethanol/0.1% diethylamine/heptane as the mobile phase to give 8-chloro-3-(cyclopropylmethyl)-N-(((1S,2S)-2-phenylcyclopentyl)methyl)-[1,2,4]triazolo[4,3-a]pyridin-7-amine, peak 1, eluting at 6.8 min. 1H NMR (400 MHz, METHANOL-d4) δ 8.05 (d, J=7.5 Hz, 1H), 7.33-7.20 (m, 5H), 7.20-7.08 (m, 1H), 6.60 (d, J=7.8 Hz, 1H), 3.48-3.36 (m, 1H), 2.97 (d, J=7.0 Hz, 2H), 2.83-2.66 (m, 1H), 2.40 (d, J=8.0 Hz, 1H), 2.23-2.05 (m, 2H), 1.93-1.76 (m, 3H), 1.57 (dd, J=12.7, 7.2 Hz, 1H), 1.26-1.13 (m, 1H), 0.70-0.56 (m, 2H), 0.39-0.25 (m, 2H). LCMS: M+1=381.16.

Provenance & Evidence