1-Methylpiperazine → HCID 44540961, compound

Participants

Reaction Conditions

Reaction Steps

To a microwave vial was added 2 ml of a solution of 6-chloro-N-[6-(1H-indol-4-yl)-1H-indazol-4-yl]-2-pyridinecarboxamide (350 mg, 0.90 mmol, prepared as described in Example 18) in DMSO (14 ml). 1-methylpiperazine (0.029 ml, 0.26 mmol) and DIPEA (0.113 ml) were added and the mixture was heated at 160° C. for 4 h under microwave irradiation. The crude reaction mixture was dissolved in DMSO/MeOH (1:1) and purified by using Mass Directed Automated Preparative HPLC (Method E). Product-containing fractions were dried under a stream of nitrogen to afford the title compound (12.8 mg).

Provenance & Evidence