反应详情

温度

150 °C

A mixture of N-(6-bromo-1H-indazol-4-yl)-2-pyridinecarboxamide (38 mg, 0.12 mmol), 1H-indol-4-ylboronic acid (23 mg, 0.14 mmol, available from Apollo), Pd(dppf)Cl2 (10 mol %, 12 mg, 0.015 mmol), aqueous sodium carbonate solution (2M, 0.18 ml, 0.36 mmol) in dioxane/water 1:1 (2 ml) was heated at 150° C. for 30 mins under microwave irradiation. The reaction mixture was filtered through a silica cartridge eluting with MeOH, then the solvent was removed in vacuo. Purification by mass directed preparative HPLC (Method B) give after evaporation of solvents the title compound as a light brown solid (21 mg).

1. filtrationThe reaction mixture was filtered through a silica cartridge
2. washeluting with MeOH
3. customthe solvent was removed in vacuo
4. customPurification by mass
5. customgive
6. customafter evaporation of solvents the title compound as a light brown solid (21 mg)