反应详情

温度

150 °C

A mixture of N-(6-bromo-1H-indazol-4-yl)-2-pyridinecarboxamide (100 mg, 0.31 mmol), (1-methyl-1H-indol-5-yl)boronic acid (65 mg, 0.37 mmol, available from Apollo), Pd(dppf)Cl2 (10 mol %, 31 mg, 0.038 mmol), aqueous sodium carbonate solution (2M, 0.468 ml, 0.94 mmol) in dioxane/water 1:1 (3 ml) was heated at 150° C. for 30 mins under microwave irradiation. The reaction mixture was filtered through a silica cartridge eluting with MeOH. The solvent was removed in vacuo. The crude compound obtained was purified by HPLC using the following conditions to provide the title compound (15 mg).

1. filtrationThe reaction mixture was filtered through a silica cartridge
2. washeluting with MeOH
3. customThe solvent was removed in vacuo
4. customThe crude compound obtained
5. customwas purified by HPLC