HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydroxyamine hydrochloride → 4,6-Dichloro-5-pyrimidinecarbaldehyde oxime
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydroxyamine hydrochloride | HCID 443297 | — |
| Reactant | Sodium Acetate | HCID 517045 | — |
| Reactant | 4,6-Dichloro-5-pyrimidinecarbaldehyde | HCID 819691 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 4,6-Dichloro-5-pyrimidinecarbaldehyde oxime | HCID 76016516 | — |
Reaction Steps
A mixture of 4,6-dichloro-5-pyrimidinecarbaldehyde (8.00 g, 44.8 mmol), NaOAc (3.7 g, 1.0 eq) and NH2OH.HCl (3.1 g, 1.0 eq) in EtOH (320 mL) was stirred at rt for 2 h. The reaction mixture was filtered, concentrated and purified by column chromatography on silica gel (dry loading, first DCM then DCM/EtOAc, 1/9) to give 4,6-dichloro-5-pyrimidinecarbaldehyde oxime as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08765768B2 |
| Source dataset | uspto-grants-2014_07 |
| ORD ID | ord-2ba7717494c54f29b575e8d272a5edbb |
| Source note | uspto-grants-2014_07 |