Water → HCID 56591901, compound

Participants

Reaction Conditions

Reaction Steps

N-[2-fluoro-4-(methylsulfonyl)phenyl]-7-(piperidin-4-yl)furo[3,2-d]pyrimidine-4-amine hydrochloride (9.8 mg, 0.023 mmol), 2,5-dichloropyrimidine (5.1 mg, 0.035 mmol) and N,N-diisopropylethylamine (9.0 mg, 0.069 mmol) were dissolved in N,N-dimethylformamide (0.5 mL) and stirred at 80° C. for 2.5 hours. Water was added to the reaction liquid, and the reaction liquid was extracted with ethyl acetate, dried over anhydrous sodium sulfate and concentrated under a reduced pressure, and the obtained residue was purified by silica gel preparative thin layer chromatography (chloroform:methanol=25:1) to give the titled compound (2.2 mg, 19%) as a yellow solid.

Provenance & Evidence