Water → HCID 56592070, compound

Participants

Reaction Steps

N-[2-Fluoro-4-(methylsulfonyl)phenyl]-7-(piperidin-4-yl)furo[3,2-d]pyrimidine-4-amine hydrochloride (10 mg, 0.023 mmol) was dissolved in pyridine (0.1 mL), a solution of 3,5-bis(trifluoromethyl)benzene-1-sulfonyl chloride (14 mg, 0.046 mmol) in anhydrous methylene chloride (0.4 mL) was added under ice-cooling, followed by stirring at room temperature for 1 hour and 45 minutes. Water was added to the reaction liquid, followed by extraction with ethyl acetate, the organic layer was dried over anhydrous sodium sulfate and concentrated under a reduced pressure, and the obtained residue was purified by silica gel preparative thin layer chromatography (chloroform:methanol=50:1) to give the titled compound (6.3 mg, 41%) as a white solid.

Provenance & Evidence