Water → HCID 56592071, compound

Participants

Reaction Steps

A solution of cyclopropanesulfonyl chloride (4 mg, 0.028 mmol) in anhydrous acetonitrile (0.2 mL), and triethylamine (10 μL, 0.069 mmol) were added to N-[2-fluoro-4-(methylsulfonyl)phenyl]-7-(piperidin-4-yl)furo[3,2-d]pyrimidine-4-amine hydrochloride (10 mg, 0.023 mmol) under ice-cooling, followed by stirring at room temperature for 2 hours. Water was added to the reaction liquid, followed by extraction with chloroform, and the organic layer was dried over anhydrous sodium sulfate and concentrated under a reduced pressure, and the obtained residue was purified by silica gel preparative thin layer chromatography (chloroform:methanol=50:1) to give the titled compound (8.5 mg, 75%) as a pale yellow solid.

Provenance & Evidence