Potassium Carbonate → HCID 56592600, compound

Participants

Reaction Steps

Under an argon atmosphere, the tert-butyl 4-{4-[(1H-benzo[d][1,2,3]triazol-1-yl)oxy]furo[3,2-d]pyrimidin-7-yl}piperidine-1-carboxylate (10 mg, 0.023 mmol) obtained in Step 7 of Example 1 and 4-(methylsulfonyl)phenol (4 mg, 0.023 mmol) were dissolved in anhydrous N,N-dimethyl formaldehyde (0.5 mL), potassium carbonate (5 mg, 0.035 mmol) was added, stirring was conducted at room temperature for 2 hours, water was added, followed by extraction with toluene. The organic layer was dried over anhydrous sodium sulfate and concentrated under a reduced pressure, and the obtained residue was purified by silica gel preparative thin layer chromatography (hexane:ethyl acetate=1:2) to give the titled compound (10 mg, 89%) as a pale yellow solid.

Provenance & Evidence