Triethylamine → HCID 66776729, compound

Participants

Reaction Steps

A solution of 2-nitrobenzoyl chloride (1.85 g, 10 mmol) in CH2Cl2 (10 mL) was slowly added to a solution of 2-(2,2,2-trifluoro-ethylsulfanyl)-pyrimidin-4-ylamine (2.1 g, 10 mmol) and triethylamine (2 g, 20 mmol) in CH2Cl2 (80 mL) between 0 and max 7° C. The mixture was stirred overnight at room temperature and then poured into ice-water. The phases were separated and the organic part was dried with Na2SO4, filtered and concentrated in vacuo to provide a viscous oil. The crude product was purified by prep-HPLC (1.5 g, 41.8%).

Provenance & Evidence