m-Chloroperbenzoic acid → HCID 46908598, compound

Participants

Reaction Steps

3-[2-(2,2,2-Trifluoro-ethylsulfanyl)-pyrimidin-4-yl]-3H-quinazolin-4-one (1.1 g, 3.25 mmol) was dissolved in 20 mL chloroform, and m-chloroperoxybenzoic acid (m-CPBA) (0.7 g, 3.57 mmol, 85% of purity) was added at room temperature. The reaction mixture was stirred for 3 hours at room temperature. Washing with sodium-thiosulfate solution and sodium-hydrogencarbonate, drying with Na2SO4 and the crude product was purified by prep-TLC and then prep-HPLC to give 3-[2-(2,2,2-trifluoro-ethylsulfinyl)pyrimidin-4-yl]-3H-quinazolin-4-one (0.35 g, 30.5%) as an off-white solid.

Provenance & Evidence