Hydrochloric Acid → HCID 136380814, compound

Participants

Reaction Steps

To a solution of tert-butyl 4-[({7-[(hydroxyamino)carbonyl]-4-oxo-3,4-dihydroquinazolin-2-yl}methyl)amino]piperidine-1-carboxylate, 1-56 (98 mg, 0.23 mmol) in methylene chloride (3.2 mL) was added 4.0 M hydrochloric acid in 1,4-dioxane (3.2 mL, 12.8 mmol). The reaction mixture was stirred at rt for 2 h. The solid was filtered and washed with DCM to afford N-hydroxy-4-oxo-2-[(piperidin-4-ylamino)methyl]-3,4-dihydroquinazoline-7-carboxamide.2[HCl] (44 mg, 48%). LC-MS: (FA) ES+ 318; 1H NMR (300 MHz, DMSO) δ 12.80 (s, 1H), 11.63 (s, 1H), 10.04 (s, 1H), 9.48-9.28 (m, 1H), 9.07 (s, 1H), 8.18 (d, J=8.3 Hz, 1H), 8.07 (d, J=1.2 Hz, 1H), 7.88 (dd, J=8.3, 1.5 Hz, 1H), 4.28 (s, 2H), 3.45-3.26 (m, 3H), 3.02-2.84 (m, 2H), 2.34-2.20 (m, 2H), 2.11-1.88 (m, 2H).

Provenance & Evidence