Phosphorus oxychloride → HCID 67283428, compound

Participants

Reaction Conditions

Reaction Steps

Into a round bottom flask was added methyl 2,4-dioxo-3-phenyl-1,2,3,4-tetrahydroquinazoline-7-carboxylate (0.21 g, 0.70 mmol) dissolved in phosphoryl chloride (3.0 mL, 32.2 mmol) and N,N-diisopropylethylamine (0.27 mL, 1.6 mmol). The reaction mixture was heated to 120° C. and stirred overnight. The mixture was then cooled to rt and concentrated. The residue was poured over ice and the resulting solid was filtered and washed with water to afford methyl 2-chloro-4-oxo-3-phenyl-3,4-dihydroquinazoline-7-carboxylate (0.17 g, 77%). LC-MS: (FA) ES+ 315.

Provenance & Evidence