4-Chlorobenzylamine → HCID 67281627, compound

Participants

Reaction Conditions

Reaction Steps

To a suspension of methyl 3-benzyl-2-chloro-4-oxo-3,4-dihydroquinazoline-7-carboxylate (0.20 g, 0.37 mmol) in isopropyl alcohol (4 mL) was added N,N-diisopropylethylamine (0.13 mL, 0.77 mmol) and p-chlorobenzylamine (0.11 mL, 0.91 mmol). The reaction mixture was heated to 100° C. and stirred for 1 h. The mixture was then cooled to rt and concentrated. The residue was purified by flash silica gel chromatography (0% to 80% EtOAc/hexanes) to afford methyl 3-benzyl-2-[(4-chlorobenzyl)amino]-4-oxo-3,4-dihydroquinazoline-7-carboxylate (0.12 g, 75%). LC-MS: (FA) ES+434.

Provenance & Evidence