HCID 136390988, compound → HCID 67282748, compound

Participants

Reaction Steps

To a solution of 2-benzyl 7-methyl 4-oxo-3,4-dihydroquinazoline-2,7-dicarboxylate (0.70 g, 2.0 mmol) in methanol (7 mL) and ethyl acetate (4 mL) was added 10% palladium on carbon (20 mg). The mixture was purged with H2 gas (3×) and stirred under an atmosphere of H2 for 1 d. The reaction mixture was then filtered through Celite, washed with MeOH and concentrated to afford 7-(methoxycarbonyl)-4-oxo-1,2,3,4-tetrahydroquinazoline-2-carboxylic acid (0.48 g, 90%). LC-MS: (FA) ES+ 251; 1H NMR (400 MHz, DMSO) δ 7.66 (d, J=8.0 Hz, 1H), 7.52 (s, 1H), 7.17 (d, J=8.2 Hz, 1H), 4.65 (s, 1H), 3.82 (s, 3H).

Provenance & Evidence